In February 2012, it was reported that Bush had joined the cast of the upcoming CBS sitcom Partners.
The remaining seven episodes of the series' initial thirteen-episode order remain unaired in the United States, though they were later aired by various international outlets.
Bush was joined in Dallas, Fort Worth, and Waco by fellow actor Adam Rodríguez.
In February 2008, she made several appearances in Texas in support of the Obama campaign in the Democratic presidential primary election.
She had major film roles in John Tucker Must Die (2006), The Hitcher (2007), and The Narrows (2008). At Westridge, she was required to participate in the theatre arts program.
From 2014 to 2017, she starred in the NBC police procedural drama series Chicago P. Bush stated: "Part of my school's requirement was to do a play.
Throughout the series, her character evolved from a trouble-making vixen to a fiercely loyal friend.
After Bush gained mainstream fame, she became a spokesperson for high-profile brands.